Concomitant Use of Antidepressants, Antipsychotics Linked to T2D Risk

For treatment of depressive symptoms, complex AAP regimens should be used judiciously with appropriate cardiometabolic monitoring.

A retrospective cohort study published in the Journal of the American Academy of Child & Adolescent Psychiatry found a substantial increase in type 2 diabetes risk in young people taking atypical antipsychotics (AAPs) concurrently with selective serotonin reuptake inhibitor (SSRIs), serotonin-norepinephrine reuptake inhibitor (SNRIs), or tricyclic antidepressants (TCA).1

As AAPs have mostly replaced first-generation antipsychotics in recent decades, their use has expanded at an even higher rate in young people compared with adults.2 There has been a particular increase in off-label use for behavioral disorders, especially in Medicaid-insured young people in the…

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